In Vitro Pharmacology

Others


  • Photodegradation
  • Rhinitis
    In Vitro Model for identification of anti-rhinitic compounds
    Model Evaluation of anti-rhinitic activity
    Test system
    • Human nasal epithelial cell line (RPMI 2650)
    • Human airway epithelial cell line (A549)
    Method
    • Treatment of cells with test compounds
    • Induction of inflammatory conditions by treatment with appropriate stimulant (HDM extract/LPS)
    • Assessment of TGF-ß2 secretion in RPMI 2650 cell line
    • Assessment of IL-6 & IL-8 in A549 cell line
    End points Quantitation of inflammatory cytokines
    X