DMPK

ADME


  • Metabolic stability
  • Aqueous solubility
  • Plasma protein binding
  • Individual protein binding
  • Permeability assessment (PAMPA, MDCK & Caco-2)
  • CYP450 enzyme inhibition
  • CYP 450 phenotyping
  • Drug-Drug interaction
  • Log P, Log D determination
  • RBC-plasma partitioning
  • Plasma stability studies
  • Dermal permeability (animal & human skin)