Nowadays, unorganized, and stressful lifestyle causes various health problems. One of these is a change in mental and behavioral health. Neuropharmacology is a branch of science deals with mental (Stress, Depression, Anxiety, Dementia) and behavioral health (Alzheimer, Parkinson, Schizophrenia). For researchers and physicians, this will be a challenging area of the medical field in the succeeding decades due to its complexity.
Dabur Research Foundation having a well-equipped neuropharmacology facility with advanced technology. The neuropharmacology facility consists of various apparatus and instruments connected digitally with the software/camera and record data instantaneously such as…
- Morris water maze for learning and memory.
- Elevated plus maze for anxiety.
- Y maze for spontaneous memory.
- Open field apparatus for locomotor activity, anxiety, and willingness to explore.
- Rotarod for motor coordination and muscle strength.
- Actophotometer for mobility/locomotion/bradykinesia.
- Passive avoidance for learning and memory.
- Pole test for motor coordination.
- Traction test for motor coordination.
- Grip strength meter for muscle grip.
- Hole poke for Neophobic behavior.
- Stereotaxic for CSF collection and injection into brain.
- Tail flick for analgesic response.
- Hot and cold plate for pain response.
- Von Frey for mechanical allodynia.
- Pressure application measurement (PAM) for mechanical sensitivity.
- Balance beam for motor coordination.
- Grid test apparatus for motor coordination.
Many animal models in neuropharmacology have been validated with appropriate study design to accomplish the desired objectives such as…
- Vincristine-induced peripheral neuropathy in rats.
- MPTP induced model of Parkinson’s disease in mice.
- Scopolamine induced dementia model in rats/mice.
- Streptozotocin (Intracerebroventricular) induced dementia model in rats/mice.
- Anti-anxiety activity using Elevated Plus Maze Test in rats/mice.
- Anti-depressant activity using Force swim test in rats.
- Anti-depressant activity using tail suspension test in rats/mice.
- Muscle relaxant activity using Rota rod test in rats/mice.
- Learning & memory potential using Morris water maze test in rats.
- Anti-stress activity using Unpredictable Chronic Stress (UCS) model in rats.
- Learning & memory potential using Y Maze test in rats.
- Streptozotocin induced neuropathic pain in rats.
- D-Gal induced ageing in rats.
