Increase in proliferation of Human/mouse Mesenchymal stem cells (MSC)/Umbillical Cord Blood stem cells (UCS)/Adipocytes stem cells (ACS) by BrdU incorporation in Human/ Murine stem cells to study Stem cells activity.

• Cell Model

  Human/ Murine stem cells

• End Point

  Increased Proliferation

• Reference Drugs

  Based on the therapeutic area under study

• Relevance

  Stem cells activity

Stem cells characterization - CD90+, CD105+ to evaluate Stem cells activity using Human/ Murine stem cells, measuring CD90, CD105 expression levels by Flow cytometry.

• Cell Model

  Human/ Murine stem cells

• End Point

  CD90, CD105 expression levels by Flow cytometry

• Reference Drugs

  Based on the therapeutic area under study

• Relevance

  Stem cells activity

Tumorigenicity potential of pluripotent stem cell injection through sub-retinal and sub-cutaneous routes in SCID mice is assessed by tumor measurement, ophthalmological examination, and histopathology of the injection site, tumor, and eye to evaluate the safety and biological behavior of the stem cells in vivo.

• Animal Model

  Mice

• End Point

  Tumor measurement, Ophthalmological Examination, histopathology of site of Injection/Tumor & eye

• Reference Drugs

  Reference cells-Hela cells

Monosodium iodoacetate (MIA) induced osteoarthritis model evaluates arthritis score, paw volume, body weight, serum biomarkers (such as TNF-alpha), radiography, and histopathology (H&E staining) of the hind paw to comprehensively assess the severity and progression of osteoarthritis in experimental subjects.

• Animal Model

  Rat

• End Point

  Arthritis Score,Paw volume,Body weight,Serum Biomarkers (TNF alpha etc.), Radiography, Histopathology (H&E) of Hind paw

• Reference Drugs

  Celecoxib