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Cellular Aging

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  • Anti-senescence effect by shortening of doubling time of human fibroblasts (WI-38)/Hayflick limitDRF/CB/AMT-01

    This assay assesses the anti-senescence effect by evaluating the shortening of the doubling time of human fibroblasts (WI-38), alongside their Hayflick number, to determine cellular longevity.

    • Cell Model

      Human fibroblasts (WI-38)

    • End Point

      Doubling Time/ Hayflick number

    • Reference Drugs

      L-Ascorbic Acid/ Resveratrol

    • Relevance

      Cellular aging
  • Senescence associated beta-galactosidase activity in diploid fibroblastDRF/CB/AMT-01

    This assay assesses senescence-associated beta-galactosidase activity in diploid fibroblasts (HFF-1) and hepatocytes (HepG2), serving as a marker for cellular aging.

    • Cell Model

      Fibroblasts (HFF-1)/ Hepatocytes (HepG2)

    • End Point

      beta-galactosidase activity

    • Reference Drugs

      L-Ascorbic Acid/ Resveratrol/ Silymarin

    • Relevance

      Cellular aging
  • Telomerase activity in cellsDRF/CB/AMT-01

    This assay assesses telomerase activity in cells, specifically in keratinocytes (HaCaT) and human peripheral blood mononuclear cells (PBMCs), to evaluate cellular aging and replicative potential.

    • Cell Model

      Keratinocytes (HaCaT)/ Human Mononuclear cells (PBMCs)

    • End Point

      Telomerase activity

    • Reference Drugs

      L-Ascorbic Acid/ Resveratrol

    • Relevance

      Cellular aging
  • Telomere lengthDRF/CB/AMT-01

    This assay assesses telomere length in human peripheral blood mononuclear cells (PBMCs) and blood samples, providing insights into cellular aging and genomic stability.

    • Cell Model

      Human Mononuclear cells (PBMCs)/ Blood Samples

    • End Point

      Telomere Length

    • Reference Drugs

      L-Ascorbic Acid/ Resveratrol

    • Relevance

      Cellular aging
  • SIRT-1 modulation in cellsDRF/CB/AMT-01

    This assay assesses SIRT-1 modulation in cells by measuring SIRT-1 activity in fibroblasts (HFF-1) and hepatocytes (HepG2), providing insights into cellular aging and metabolic regulation.

    • Cell Model

      Fibroblasts (HFF-1)/ Hepatocytes (HepG2)

    • End Point

      SIRT-1 activity

    • Reference Drugs

      L-Ascorbic Acid/ Resveratrol/ Silymarin

    • Relevance

      Cellular aging
  • Comet assay in cellsDRF/CB/AMT-01

    This assay assesses DNA damage and repair in cells using the Comet assay, measuring comet length in fibroblasts (HFF-1) and hepatocytes (HepG2) as an indicator of genomic integrity.

    • Cell Model

      Fibroblasts (HFF-1)/ Hepatocytes (HepG2)

    • End Point

      Comet length

    • Reference Drugs

      L-Ascorbic Acid/ Resveratrol/ Silymarin

    • Relevance

      Cellular aging
  • D-Galactose induced systemic ageing in RatsPCY/COV-01

    This study assesses D-galactose-induced systemic aging in rats through a comprehensive analysis of behavioral parameters (Y-maze, elevated plus maze, Morris water maze, and forced swim test), body weight changes, cytokine levels, oxidative stress markers in blood and major organs, the aging marker KLOTHO in kidneys, skin histology, as well as hematological and biochemical profiles.

    • Animal Model

      Rat

    • End Point

      Behavioural parameters (Y maze, EPM, Morri's water and forced swim test),body weights, cytokines and oxidative stress markers in blood and major vital organs, level of ageing marker KLOTHO in kidneys, skin histology, haemetology and biochemistry

    • Reference Drugs

      Resveratol