MALE SEXUAL HEALTH

• Phosphodiesterase 5 (PDE5) Inhibition cell free assayDRF/CB/MSH-01

  Phosphodiesterase 5 (PDE5) Inhibition cell free assay to evaluate Erectile Dysfunction using Eahy.926/ cell free, measuring PDE5 inhibition via cGMP modulation.

  • Cell Model

    Eahy.926/ cell free

  • End Point

    PDE5 inhibition via cGMP modulation

  • Reference Drugs

    Sildenafil

  • Relevance

    Erectile Dysfunction
• cGMP accumulation / sGC activityDRF/CB/MSH-02

  cGMP accumulation / sGC activity to evaluate Erectile Dysfunction using Eahy.926/ cell free, measuring cGMP modulation.

  • Cell Model

    Eahy.926/ cell free

  • End Point

    cGMP modulation

  • Reference Drugs

    Sildenafil

  • Relevance

    Erectile Dysfunction
• Nitric Oxide Release in Endothelial cellsDRF/CB/MSH-03

  Nitric Oxide Release in Endothelial cells to evaluate Erectile Dysfunction using Eahy.926/ cell free, measuring NO levels by Griess reagent.

  • Cell Model

    Eahy.926/ cell free

  • End Point

    NO levels by Griess reagent

  • Reference Drugs

    Sildenafil

  • Relevance

    Erectile Dysfunction

• Aphrodisiac activity using mating behavior test PCY/SW-01

  Aphrodisiac activity using mating behavior test in male and female rats, measuring number of mounts, intromission time, testosterone level, and body weight.

  • Animal Model

    Male & Female Wistar/ SD Rats

  • End Point

    No. of mounting, Intromission time, Latency, Testosterone level,Body Weight, etc.

  • Reference Drugs

    Ashwagandha
• Erectile dysfunction: Isolated tissue preparation - Corpora cavernosa contraction testPCY/SW-02

  Erectile dysfunction model with isolated tissue preparation, measuring contraction and relaxation of corpora cavernosa.

  • Animal Model

    Rat

  • End Point

    % Contraction,% Relaxation of CC tissue

  • Reference Drugs

    Sildenafil Citrate