Scientific Publications
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Lubna Siddiqui, Nazeer Hasan, Pawan K. Mishra, Neha Gupta, Anu T. Singh, Alka Madaan, Manu Jaggi, Suma Saad, Adam Ekielski, Zeenat Iqbal, Prashant Kesharwani, Sushama Talegaonkar. CD44 mediated colon cancer targeting mutlifaceted lignin nanoparticles: Synthesis, in vitro characterization and in vivo efficacy studies. International Journal of Pharmaceutics 643 (2023) 123270.
https://www.sciencedirect.com/science/article/abs/pii/S0378517323006907 -
Nidhi Gupta, Ritu Verma, Alka Madaan, Kriti Soni, Anu T. Singh, Manu Jaggi, Pallavi Kushwaha & Surinder P. Singh. Neuroprotective Potential of Ayurvedic Herbal Extracts: A Promising Avenue in the Therapeutic Management of Alzheimer Disease. Conference paper. 2022, Polymeric Biomaterials and Bioengineering pp 149–157.
https://link.springer.com/chapter/10.1007/978-981-19-1084-5_14
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Gupta, Navika & Chandra, Saurabh & Singh, Anu & Jaggi, Manu. (2022). Characterization of Lantana camara roots (Pentacyclic Triterpenoid) and Mutagenicity Testing of extracted Oleanolic acid Using Salmonella typhimurium.
10.21203/rs.3.rs-2054094/v1 -
Balmforth D, Swales JA, Silpa L, Dunton A, Davies KE, Davies SG, Kamath A, Gupta J, Gupta S, Masood MA, McKnight Á, Rees D, Russell AJ, Jaggi M, Uppal R. Evaluating the efficacy and safety of a novel prophylactic nasal spray in the prevention of SARS-CoV-2 infection: A multi- centre, double blind, placebo-controlled, randomised trial. J Clin Virol. 2022 Oct;155:105248. doi: 10.1016/j.jcv.2022.105248. Epub 2022 Jul 25. PMID: 35952426; PMCID: PMC9313533.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313533/pdf/main.pdf
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Satyendra Kumar a, Padmanabha Rugvedi a, *, Kamaraj Mani b, Arun Gupta. Evaluation of anti- inflammatory and immunomodulatory activity of Chyawanprash on particulate matter-induced pulmonary disease in mice. Journal of Ayurveda and Integrative Medicine 12 (2021) 649e656.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8642710/pdf/main.pdf -
Dubey VK, Budhauliya A, Jaggi M, Singh AT, Rajput SK. Tumor-suppressing effect of bartogenic acid in ovarian (SKOV-3) xenograft mouse model. Naunyn Schmiedebergs Arch Pharmacol. 2021 Aug;394(8):1815-1826. doi: 10.1007/s00210-021-02088-0. Epub 2021 Jul 13. Erratum in: Naunyn Schmiedebergs Arch Pharmacol. 2021 Nov;394(11):2349. PMID: 34255109.
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Dubey VK, Madan S, Rajput SK, Singh AT, Jaggi M, Mittal AK. Single and repeated dose (28 days) intravenous toxicity assessment of bartogenic acid (an active pentacyclic triterpenoid) isolated from Barringtonia racemosa (L.) fruits in mice. Curr Res Toxicol. 2021 Oct 28;3:100057. doi: 10.1016/j.crtox.2021.10.004. PMID: 36504921; PMCID: PMC9731886.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9731886/pdf/main.pdf
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Asiya Mahtab, Syed Arman Rabbani, Yub Raj Neupane, Shweta Pandey, Adil Ahmad, Mohd Ahmed Khan, Neha Gupta, Alka Madaan, Manu Jaggi, Nidhi Sandal, Harish Rawat, Mohd Aqil, Sushama Talegaonkar. Facile functionalization of Teriflunomide-loaded nanoliposomes with Chondroitin sulphate for the treatment of Rheumatoid arthritis. Carbohydr Polym, 2020 Dec 15;250:116926.
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Mishra H, Mishra PK, Iqbal Z, Jaggi M, Madaan A, Bhuyan K, Gupta N, Gupta N, Vats K, Verma R, Talegaonkar S. Co-Delivery of Eugenol and Dacarbazine by Hyaluronic Acid-Coated Liposomes for Targeted Inhibition of Survivin in Treatment of Resistant Metastatic Melanoma. Pharmaceutics. 2019 Apr 3;11(4). pii: E163. doi: 10.3390/pharmaceutics11040163.
https://www.ncbi.nlm.nih.gov/pubmed/30987266 -
Madaan A, Verma R, Singh AT, Jaggi M. Review of Hair Follicle Dermal Papilla cells as in vitro screening model for hair growth. Int J Cosmet Sci. 2018 Aug 25 (ahead of print). https://www.ncbi.nlm.nih.gov/pubmed/30144361
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Mishra H, Mishra PK, Ekielski A, Iqbal Z, Jaggi M, Talegaonkar S. Functionalized nanoliposomes loaded with anti survivin and anti angiogenic agents to enhance the activity of chemotherapy against melanoma by 4-pronged action. Med Hypotheses. 2018 Jul;116:141-146. doi: 10.1016/j.mehy.2018.05.002. Epub 2018 May 8. PMID: 29857900.
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Mishra H, Mishra PK, Ekielski A, Jaggi M, Iqbal Z, Talegaonkar S. Melanoma treatment: from conventional to nanotechnology. .J Cancer Res Clin Oncol. 2018 Dec;144(12):2283 2302. doi: 10.1007/s00432-018-2726-1. Epub 2018 Aug 9.
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Negi LM, Talegaonkar S, Jaggi M, Verma AK. Hyaluronated imatinib liposomes with hybrid approach to target CD44 and P-gp overexpressing MDR cancer: an in-vitro, in-vivo and mechanistic investigation. J Drug Target. 2019 Feb;27(2):183-192. doi: 10.1080/1061186X.2018.1497039. Epub 2018 Aug 14. PMID: 29972336.
https://www.tandfonline.com/doi/full/10.1080/1061186X.2018.1497039
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Gupta A, Madaan A, Srivastava R, Kumar S, Sastry JLN. Evaluation of antioxidant, immunostimulatory and antifatigue properties of Dashmularishta using in vitro and in vivo assays. Ind. J. Exp biol 2018, 56(08):598-603.
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Arun Gupta, Satyendra Kumar, Rashmi Rajput3, Ruchi Srivastava, Rajiv K. Rai1, J. L. N. Sastry2. Evaluation of Ratnaprash for its effect on strength, stamina and fatigue using swim endurance test and biochemical estimation in swiss albino mice. Ancient Sci Life 2015;35:26-3. doi:
10.4103/0257-7941.165626https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4623629/?report=printable
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Shraibom N, Madaan A, Joshi V, Verma R, Chaudhary A, Mishra G, Awasthi A, Singh AT, Jaggi
M. Evaluation of in vitro anti-psoriatic activity of a novel polyherbal formulation by multiparametric analysis. Antiinflamm Antiallergy Agents Med Chem. 2017 16(2): 94 – 111. https://www.ncbi.nlm.nih.gov/pubmed/28730954
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Madaan A, Joshi V, Kishore A, Verma R, Singh AT, Jaggi M, Sung YK. In vitro Hair Growth Promoting Effects of Naringenin and Hesperetin on Human Dermal Papilla Cells and Keratinocytes. American Journal of Dermatology and Venereology. 2017 6(3): 51-57. http://article.sapub.org/10.5923.j.ajdv.20170603.02.html
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Pandit S, Kanjilal S, Awasthi A, Chaudhary A, Banerjee D, Bhatt BN, Narwaria A, Singh R, Dutta K, Jaggi M, Singh AT, Sharma N, Katiyar CK. Evaluation of herb-drug interaction of a polyherbal
Ayurvedic formulation through high throughput cytochrome P450 enzyme inhibition assay. J Ethnopharmacol. 2017 Feb 2;197:165-172.
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Gopalakrishna Pillai GK, Bharate SS, Awasthi A, Verma R, Mishra G, Singh AT, Jaggi M, Mithal A, Vishwakarma RA. Antidiabetic potential of polyherbal formulation DB14201: Preclinical development, safety and efficacy studies. J Ethnopharmacol. 2017 Feb 2;197:218-230. https://www.ncbi.nlm.nih.gov/pubmed/27457691
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Setia M, Meena K, Madaan A, Srikanth N, Dhiman K, Sastry JLN. In vitro Studies on Antidiabetic Potential of New Dosage Forms of AYUSH 82. J Drug Res Ayur Sci 2017 2(1): 1-9. http://www.jaypeejournals.com/eJournals/ShowText.aspx?ID=13448&Type=FREE&TYP=TOP &IN=_eJournals/images/JPLOGO.gif&IID=1048&Value=55&isPDF=YES
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"Development of novel hair growth promoters addressing various forms of Alopecia" Oral presentation at 6th International Conference and Expo on Cosmetology, Trichology & Aesthetic Practices, April 13-14, 2017 Dubai, UAE. Singh AT, Unnithan JS, Madaan A, Verma R, Kumari S, Gupta N, Jaggi M.
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"Development of novel products for improvement of skin health" Oral presentation at 6th International Conference and Expo on Cosmetology, Trichology & Aesthetic Practices, April 13- 14, 2017 Dubai, UAE. Jaggi M, Madaan A, Verma R, Singh M, Gupta N, Gupta N, Singh AT.
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"Development of a novel polyherbal topical formulation for the management of psoriasis". International Conference on Psoriasis and Skin Specialists Meeting, December 08-09, 2016 Dallas, USA. Jaggi M, Shraibom N, Madaan A, Verma R, Gupta N, Chaudhary A, Mishra G, Singh P, Dobhal S, Singh AT.
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Tariq M, Alam MA, Singh AT, Panda AK, Talegaonkar S. Surface decorated nanoparticles as surrogate carriers for improved transport and absorption of epirubicin across the gastrointestinal tract: Pharmacokinetic and pharmacodynamic investigations. Int J Pharm. 2016 Mar 30;501(1- 2):18-31. doi: 10.1016/j.ijpharm.2016.01.054. Epub 2016 Jan 23. PMID: 26812610.
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Afzal O, Akhtar MS, Kumar S, Ali MR, Jaggi M, Bawa S. Hit to lead optimization of a series of N-[4-(1,3-benzothiazol-2-yl)phenyl]acetamides as monoacylglycerol lipase inhibitors with potential anticancer activity. Eur J Med Chem. 2016 Oct 4;121:318-330. doi: 10.1016/j.ejmech.2016.05.038. Epub 2016 May 21. PMID: 27267002.
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Tariq M, Alam MA, Singh AT, Panda AK, Talegaonkar S. Improved oral efficacy of epirubicin through polymeric nanoparticles: pharmacodynamic and toxicological investigations. Drug Deliv. 2016 Oct;23(8):2990-2997. doi: 10.3109/10717544.2015.1136713. Epub 2016 Jan 22. PMID:
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"ANTI-PSORIATIC POTENTIAL AND SAFETY OF A NOVEL POLYHERBAL
FORMULATION" presented as eposter (P182) in 5th congress of the psoriasis international network, 7-9th July, 2016, Paris. Shraibom N, Madaan A, Verma R, Singh P, Kar R, Dobhal S, Chaudhary A, Mishra G, Awasthi A, Mookkan Jeyamurugan, T. Singh A., Jaggi M.
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"DEVELOPMENT OF A NOVEL POLYHERBAL TOPICAL FORMULATION FOR THE
MANAGEMENT OF ECZEMA" Oral presentation in 7th European Dermatology Congress, June 13-15, 2016, Alicante, Spain (DOI: 10.4172/2155-9554.C1.032). Singh AT, Shraibom N, Madaan A, Verma R, Chaudhary A, Mishra G, Singh P, Kar R, Dobhal S, T., Jaggi M.
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"EVALUATION OF ANTI-PSORIATIC POTENTIAL OF A NOVEL POLYHERBAL FORMULATION BY MULTIPARAMETRIC ANALYSIS" Abstract ID: ATH16ABS-0416.
eposter in 13th EADV Spring symposium, 19-22th May 2016, Athens, Greece. Shraibom N, Madaan A, Verma R, Joshi V, Meena K, Chaudhary A, Mishra G, Awasthi A, T. Singh A, Jaggi M.
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Gupta A, Srivastava R, Setia M, Madaan A, Sastry JLN and Rai RK. Evaluation of Swarna Guggulu in management of arthritis basis in vitro anti-inflammatory efficacy and ingredient-based benefits. Annals of Phytomedicine 2016 5(1): 35-39.
http://ukaazpublications.com/attached/publications/35-39.pdf
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Tariq M, Singh AT, Iqbal Z, Ahmad FJ, Talegaonkar S. Investigative Approaches for Oral Delivery of Anticancer Drugs: A Patent Review. Recent Pat Drug Deliv Formul. 2016;10(1):24-43. doi: 10.2174/1872211309666150827102816. PMID: 26310247.
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Madaan A, Verma R, Kumar V, Singh AT, Jain SK, Jaggi M. 1,8-Naphthyridine Derivatives: A Review of Multiple Biological Activities. Arch Pharm (Weinheim). 2015 Dec;348(12):837-60. https://www.ncbi.nlm.nih.gov/pubmed/26548568
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Madaan A, Kanjilal S, Gupta A, Sastry JLN, Verma R, Singh AT, Jaggi M. Evaluation of immunostimulatory activity of Dabur Chyawanprash using in vitro assays. Ind J Exp Biol. 2015 Mar;53(03):158-63.
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Cellular mechanisms mediating the anticancer activity of a novel polyherbal formulation. Nadav Menahem Shraibom, Manu Jaggi, Anu T Singh, Ritu Verma, Alka Madaan, Pratibha Singh, Anshumali Awasthi, Vidushi Joshi, Amitesh Kishore, Sheetal Dobhal, Ronodip Kar, Kalpana Meena. Abstract #151470, American Society of Clinical Oncology (ASCO) 2015, Accepted for publication in JCO. https://ascopubs.org/doi/10.1200/jco.2015.33.15_suppl.e13590
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Evaluation of immunostimulatory activity of Chyawanprash using in vitro assays. Madaan A, Kanjilal S, Gupta A, Sastry JL, Verma R, Singh AT, Jaggi M. Indian J Exp Biol. 2015 Mar;53(3):158-63.
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Hyaluronan coated liposomes as the intravenous platform for delivery of imatinib mesylate in MDR colon cancer. Negi LM, Jaggi M, Joshi V, Ronodip K, Talegaonkar S. Int J Biol Macromol. 2015 Feb;73:222-35.
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Hyaluronic acid decorated lipid nanocarrier for MDR modulation and CD-44 targeting in colon adenocarcinoma. Negi LM, Jaggi M, Joshi V, Ronodip K, Talegaonkar S. Int J Biol Macromol. 2015 Jan;72:569-74.
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Biodegradable polymeric nanoparticles for oral delivery of epirubicin: In vitro, ex vivo, and in vivo investigations. Tariq M, Alam MA, Singh AT, Iqbal Z, Panda AK, Talegaonkar S. Colloids Surf B Biointerfaces. 2015 Apr 1;128:448-56.
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A stepwise procedure for isolation of murine bone marrow and generation of dendritic cells. Madaan A, Verma R, Singh AT, Jain SK, Jaggi M. J Biol Methods 2014 Vol 1, e1.
http://www.jbmethods.org/jbm/article/view/12/6 -
Surface engineered nanostructured lipid carriers for targeting MDR tumor: Part I. Synthesis, characterization and in vitro investigation. Negi LM, Talegaonkar S, Jaggi M, Verma AK, Verma R, Dobhal S, Kumar V. Colloids Surf B Biointerfaces. 2014 Nov 1;123:600-9.
http://www.ncbi.nlm.nih.gov/pubmed/25454761 -
Surface engineered nanostructured lipid carriers for targeting MDR tumor: Part II. In vivo biodistribution, pharmacodynamic and hematological toxicity studies. Negi LM, Talegaonkar S, Jaggi M, Verma AK, Verma R, Dobhal S, Kumar V. Colloids Surf B Biointerfaces. 2014 Nov 1;123:610-5.
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Kumar S, Madaan A, Verma R, Gupta A, Sastry JLN. In vitro anti-inflammatory effects of Mahanarayan oil formulations using dendritic cells based assay. Annals of Phytomedicine 2014 Dec;3(2): 40-45.
http://ukaazpublications.com/attached/publications/article%20(40-45).pdf
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Zafar S, Negi LM, Verma AK, Kumar V, Tyagi A, Singh P, Iqbal Z, Talegaonkar S. Sterically stabilized polymeric nanoparticles with a combinatorial approach for multi drug resistant cancer: in vitro and in vivo investigations. Int J Pharm. 2014 Dec 30;477(1-2):454-68. doi: 10.1016/j.ijpharm.2014.10.061. Epub 2014 Nov 1. PMID: 25445525.
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3D-QSAR study of benzotriazol-1-yl carboxamide scaffold as monoacylglycerol lipase inhibitors. Afzal O, Kumar S, Kumar R, Jaggi M, Bawa S. J Pharm Bioallied Sci. 2014 Oct;6(4):260-6.
http://www.ncbi.nlm.nih.gov/pubmed/25400409 -
Afzal O, Kumar S, Kumar R, Firoz A, Jaggi M, Bawa S. Docking based virtual screening and molecular dynamics study to identify potential monoacylglycerol lipase inhibitors. Bioorg Med Chem Lett. 2014 Aug 15;24(16):3986-96. doi: 10.1016/j.bmcl.2014.06.029. Epub 2014 Jun 19.
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A review on anticancer potential of bioactive heterocycle quinoline. Afzal O, Kumar S, Haider MR, Ali MR, Kumar R, Jaggi M, Bawa S. Eur J Med Chem. 2014 Jul 24. pii: S0223-5234(14)00651-5.
http://www.ncbi.nlm.nih.gov/pubmed/25073919 -
Addressing the potential toxicities of the non-specific P-glycoprotein modulation by amalgamation with targeted approach in MDR tumors. Negi LM, Jaggi M, Talegaonkar S.Med Hypotheses. 2014 Feb;82(2):240-2.
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Development of protocol for screening the formulation components and the assessment of common quality problems of nano-structured lipid carriers. Negi LM, Jaggi M, Talegaonkar S. Int J Pharm. 2014 Jan 30;461(1-2):403-
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Pharmacokinetic evaluation of C-3 modified 1,8-naphthyridine-3-carboxamide derivatives with potent anticancer activity: lead finding. Awasthi A, Lohani M, Singh MK, Singh AT, Jaggi M. J Enzyme Inhib Med Chem. 2014 Oct;29(5):710-21.
http://www.ncbi.nlm.nih.gov/pubmed/24156741 -
Sustained Release Cisplatin from a Microsphere Formulation Demonstrates Improved Safety and Efficacy in a Xenograft Bladder Cancer Rodent Model. Kamraj Mani, Vinod Sanna, Phillip Blaskovich, Xiao-Pei Guan, Ritu Verma, Archna Mathur, Howard Sard, Anu Singh, Manu Jaggi and Rachit Ohri, World Conference on Interventional Oncology (WCIO), May 11-14, 2014, New York City, NY, USA.
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Cisplatin Microspheres Demonstrate Improved Cytotoxicity Profile against 6 Cancer Cell Lines. Bhanvi Mishra, Shekhar Dhokai, Ritu Verma, Phil Blaskovich, Xiao-Pei Guan, Archna Mathur, Howard Sard, Manu Jaggi, Anu Singh, Rachit Ohri . World Conference on Interventional Oncology (WCIO), May 16-19, 2013, New York City, NY, USA.
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"in vitro screening tools to accelerate new drug discovery: Alternatives to animal testing" Best poster award at Ramanbhai Foundation 6th International Symposium -Advances in New Drug Discovery Technologies And Translational Research" held at Zydus Research Centre at Ahmedabad, India, 4th-6th Feb 2013. Madaan A, Joshi V, Verma R, Singh AT, Jaggi M.
http://www.rbfsymposium.net/Abtractbook_2013.pdf -
A validated stability-indicating LC method for estimation of etoposide in bulk and optimized self- nano emulsifying formulation: Kinetics and stability effects. Akhtar N, Talegaonkar S, Khar RK, Jaggi M. Saudi Pharm J. 2013 Jan;21(1):103-11.
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Self-nanoemulsifying lipid carrier system for enhancement of oral bioavailability of etoposide by P-glycoprotein modulation: in vitro cell line and in vivo pharmacokinetic investigation. Akhtar N, Talegaonkar S, Khar RK, Jaggi M. J Biomed Nanotechnol. 2013 Jul;9(7):1216-29.
http://www.ncbi.nlm.nih.gov/pubmed/23909136 -
Anti-inflammatory activity of a naphthyridine derivative (7-chloro-6-fluoro-N-(2-hydroxy-3-oxo- 1-phenyl-3-(phenylamino)propyl)-4-oxo-1-(prop-2-yn-1-yl)-1,4-dihydro-1,8-naphthyridine-3- carboxamide) possessing in vitro anticancer potential. Alka Madaan, Vivek Kumar, Ritu Verma, Anu T. Singh, S.K. Jain, Manu Jaggi. International Immunopharmacology, Volume 15, Issue 3, March 2013, Pages 606–613.
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Application of a liquid chromatography-electrospray mass spectrometry (LC/MS) method to the biodistribution and excretion studies of novel 5'-chloro-2, 3-didehydroindolo (2', 3': 2, 3) betulinic acid (DRF-4012) in tumour-bearing mice. Mishra G, Singh MK, Awasthi A, Singh AT, Jaggi M, Ahmad FJ. Xenobiotica. 2013 Jun;43(6):548-60.
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Efficiency and mechanism of intracellular paclitaxel delivery by novel nanopolymer-based tumor- targeted delivery system, Nanoxel(TM). Madaan A, Singh P, Awasthi A, Verma R, Singh AT, Jaggi M, Mishra SK, Kulkarni S, Kulkarni H. Clin Transl Oncol. 2013 Jan;15(1):26-32.
http://www.ncbi.nlm.nih.gov/pubmed/22855169 -
Negi LM, Jaggi M, Talegaonkar S. A logical approach to optimize the nanostructured lipid carrier system of irinotecan: efficient hybrid design methodology. Nanotechnology. 2013 Jan 11;24(1):015104. doi: 10.1088/0957-4484/24/1/015104. Epub 2012 Dec 7. PMID: 23221112.
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Negi LM, Talegaonkar S, Jaggi M, Ahmad FJ, Iqbal Z, Khar RK. Role of CD44 in tumour progression and strategies for targeting. J Drug Target. 2012 Aug;20(7):561-73. doi: 10.3109/1061186X.2012.702767. PMID: 22758394.
Role of CD44 in tumour progression and strategies for targeting - PubMed (nih.gov)
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Akhtar N, Ahad A, Khar RK, Jaggi M, Aqil M, Iqbal Z, Ahmad FJ, Talegaonkar S. The emerging role of P-glycoprotein inhibitors in drug delivery: a patent review. Expert Opin Ther Pat. 2011 Apr;21(4):561-76. doi: 10.1517/13543776.2011.561784. Epub 2011 Feb 26. PMID: 21413912.
The emerging role of P-glycoprotein inhibitors in drug delivery: a patent review - PubMed (nih.gov)
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LC–UV Detection of 5′-Chloro-2, 3-didehydroindolo (2′, 3′:2, 3) betulinic Acid in Rat Plasma and Its Application to a Pharmacokinetic Study. Gautam Mishra, Anshumali Awasthi, Manoj Kumar Singh, Manu Jaggi, Farhan J Ahmed.
Chromatographia 2011; 73(3):281-289.http://link.springer.com/article/10.1007%2Fs10337-010-1862-9
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Evaluation of 5-hydroxy-2,3-diaryl (substituted)-cyclopent-2-en-1-ones as cis-restricted analogues of combretastatin A-4 as novel anti angiogenic and anticancer agents. Vinod Kumar Sanna, Manu Jaggi, Vadlapudi Kumar, Anand C Burman .Investigational New Drugs, 2010, 28(4):363-380.
http://www.ncbi.nlm.nih.gov/pubmed/19424664 -
Bansal T, Akhtar N, Jaggi M, Khar RK, Talegaonkar S. Novel formulation approaches for optimising delivery of anticancer drugs based on P-glycoprotein modulation. Drug Discov Today. 2009 Nov;14(21-22):1067-74. doi: 10.1016/j.drudis.2009.07.010. Epub 2009 Aug 6. PMID:
19647803.
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Eclipta alba extract with potential for hair growth promoting activity." Kakali Datta, Anu T Singh, Ashok Mukherjee, Beena Bhat, B Ramesh and Anand C Burman. J Ethnopharmacol. 2009; 124(3): 450-6.
http://www.ncbi.nlm.nih.gov/pubmed/19481595 -
Singh AK, Chaurasiya A, Jain GK, Awasthi A, Asati D, Mishra G, Khar RK, Mukherjee R. High performance liquid chromatography method for the pharmacokinetic study of bicalutamide SMEDDS and suspension formulations after oral administration to rats. Talanta. 2009 Jun 15;78(4- 5):1310-4. doi: 10.1016/j.talanta.2009.01.058. Epub 2009 Feb 10. PMID: 19362193.
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Bansal T, Jaggi M, Khar RK, Talegaonkar S. Emerging significance of flavonoids as P- glycoprotein inhibitors in cancer chemotherapy. J Pharm Pharm Sci. 2009;12(1):46-78. doi: 10.18433/j3rc77. PMID: 19470292.
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Singh AK, Chaurasiya A, Awasthi A, Mishra G, Asati D, Khar RK, Mukherjee R. Oral bioavailability enhancement of exemestane from self-microemulsifying drug delivery system (SMEDDS). AAPS PharmSciTech. 2009;10(3):906-16. doi: 10.1208/s12249-009-9281-7. Epub 2009 Jul 17. PMID: 19609837; PMCID: PMC2802159.
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1,8-Naphthyridine-3-carboxamide derivatives with anticancer and anti-inflammatory activity. Kumar V, Jaggi M, Singh AT, Madaan A, Sanna V, Singh P, Sharma PK, Irchhaiya R, Burman AC. Eur J Med Chem. 2009 Aug;44(8):3356-62.
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Anticancer and immunomodulatory activities of novel 1,8-naphthyridine derivatives". Kumar V, Madaan A, Sanna VK, Vishnoi M, Joshi N, Singh AT, Jaggi M, Sharma PK, Irchhaiya R, Burman AC. J Enzyme Inhibition Med Chem. 2009 Oct; 24(5):1169-
78.http://informahealthcare.com/doi/abs/10.1080/14756360802696802
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Synthesis of 1-(2,6-dichlorophenyl)-3-methylene-1,3-dihydro-indol-2-one derivatives and in vitro anticancer evaluation against SW620 colon cancer cell line. Virsodia V, Manvar A, Upadhyay K, Loriya R, Karia D, Jaggi M, Singh A, Mukherjee R, Shaikh MS, Coutinho EC, Shah A. Eur J Med Chem 2008 Jan 25, Eur J Med Chem Mar 2009; 44(3):1355-1362.
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Sengupta P, Meena K, Mukherjee R, Jain SK, Maithal K. Optimized conditions for high-level expression and purification of recombinant human interleukin-2 in E. coli. Indian J Biochem Biophys. 2008 Apr;45(2):91-7. PMID: 21086721.
https://pubmed.ncbi.nlm.nih.gov/21086721/ PDF NOT FOUND
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Singh AK, Chaurasiya A, Singh M, Upadhyay SC, Mukherjee R, Khar RK. Exemestane loaded self-microemulsifying drug delivery system (SMEDDS): development and optimization. AAPS PharmSciTech. 2008;9(2):628-34. doi: 10.1208/s12249-008-9080-6. Epub 2008 May 13. PMID:
18473177; PMCID: PMC2976939.
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Modulation of key signal transduction molecules by a novel peptide combination effective for the treatment of gastrointestinal carcinomas. Anu T Singh*, Manu Jaggi, Sudhanand Prasad, Sarjana Dutt, Gurvinder Singh, Kakali Datta, Praveen R, Vinod K Sanna, Rama Mukherjee, Anand C Burman. Investigational New Drugs 2008; 26(6):505-516.
http://www.springerlink.com/index/a9vh625624m484km.pdf -
Anticancer activity of a peptide combination in gastrointestinal cancers targeting multiple neuropeptide receptors. Manu Jaggi, Sudhanand Prasad, Anu T Singh, Praveen R, Sarjana Dutt, Archana Mathur, Rajan Sharma, Neena Gupta, Rinku Ahuja, Rama Mukherjee, Anand C. Burman. Investigational New drugs 2008 Jan 24;26(6):489- 504.
http://www.springerlink.com/index/743G8422HJ285120.pdf -
Protective effects of Terminalia arjuna against Doxorubicin-induced cardiotoxicity. Gurvinder Singh, Anu T. Singh, Aji Abraham, Beena Bhat, Ashok Mukherjee, Ritu Verma, Shiv K. Agarwal, Shivesh Jha, Rama Mukherjee, Anand C. Burman. J Ethnopharmacol 2008 Apr 17, Epub 2008 Feb 3; 117(1):123-9.
http://www.ncbi.nlm.nih.gov/pubmed/18346858 -
Pre-clinical evidence for altered absorption and biliary excretion of irinotecan (CPT-11) in combination with quercetin: possible contribution of P-glycoprotein. Bansal T, Awasthi A, Jaggi M, Khar RK, Talegaonkar S. Life Sci. 2008 Aug 15; 83(7-8):250-9.
http://www.ncbi.nlm.nih.gov/pubmed/18619980 -
Development and validation of reversed phase liquid chromatographic method utilizing ultraviolet detection for quantification of irinotecan (CPT-11) and its active metabolite, SN-38, in rat plasma and bile samples: Application to pharmacokinetic studies. Tripta Bansal, Anshumali Awasthi, Manu Jaggi, Roop K. Khar, Sushama Talegaonkar. Talanta. Epub 2008 May 4, 2008 Sep 15; 76(5):1015-21.
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Synthesis of functionalized amino acid derivatives as new pharmacophores for designing anticancer agents. Vivek Kumar; Mukesh M. Mudgal; Nidhi Rani; Amrita Jha; Manu Jaggi; Anu T. Singh; Vinod K. Sanna; Pratibha Singh; Pramod K. Sharma; Raghuveer Irchhaiya; Anand C. Burman. J Enzyme Inhibition and Med Chem. 2008 Aug 11:1
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Synthesis and cytotoxic activity of heterocyclic ring-substituted betulinic acid derivatives. Vivek Kumar, Nidhi Rani, Pawan Aggarwal, Vinod K. Sanna, Anu T. Singh, Manu Jaggi, Narendra Joshi, Pramod K. Sharma, Raghuveer Irchhaiya, Anand C. Burman. Bioorg & Med Chem Lett. 2008 Sep 15; 18(18):5058–5062
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Effect of P-glycoprotein inhibitor, verapamil, on oral bioavailability and pharmacokinetics of irinotecan in rats. Bansal T, Mishra G, Jaggi M, Khar RK, Talegaonkar S. Epub. 2008 Dec 24. Eur J Pharm Sci. 2009 Mar 2; 36(4-5):580-90.
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Pharmacological evaluation of C-3 modified Betulinic acid derivatives with potent anticancer activity. Rajendran P, Jaggi M, Singh MK, Mukherjee R, Burman AC. Invest New Drugs 2007 Sep 13, Invest New Drugs 2008; 26(1):25-34
http://www.springerlink.com/index/RH4663740V635P60.pdf -
Kumar D, Tomar RS, Deolia SK, Srivastava R, Mitra M, Tyagi S. Isolation and characterization of degradation impurities in epirubicin hydrochloride injection. J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Jun 15;869(1-2):45-53. doi: 10.1016/j.jchromb.2008.05.014. Epub 2008 May 24. PMID: 18539101.
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Kothari K, Prasad S, Korde A, Mukherjee A, Mathur A, Jaggi M, Venkatesh M, Pillai AM, Mukherjee R, Ramamoorthy N. 99mTc(CO)3-VIP analogues: preparation and evaluation as tumor imaging agent. Appl Radiat Isot. 2007 Apr;65(4):382-6. doi: 10.1016/j.apradiso.2006.11.001. Epub 2006 Dec 27. PMID: 17194598.
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Gurjar MK, Wakharkar RD, Singh AT, Jaggi M, Borate HB, Shinde PD, Verma R, Rajendran P, Dutt S, Singh G, Sanna VK, Singh MK, Srivastava SK, Mahajan VA, Jadhav VH, Dutta K, Krishnan K, Chaudhary A, Agarwal SK, Mukherjee R, Burman AC. Synthesis and evaluation of 4/5-hydroxy-2,3-diaryl(substituted)-cyclopent-2-en-1-ones as cis-restricted analogues of
combretastatin A-4 as novel anticancer agents. J Med Chem. 2007 Apr 19;50(8):1744-53. doi: 10.1021/jm060938o. Epub 2007 Mar 21. PMID: 17373779.
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Kumar D, Tomar RS, Deolia SK, Mitra M, Mukherjee R, Burman AC. Isolation and characterization of degradation impurities in docetaxel drug substance and its formulation. J Pharm Biomed Anal. 2007 Mar 12;43(4):1228-35. doi: 10.1016/j.jpba.2006.10.015. Epub 2006 Nov 28.
PMID: 17126518.
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Bombesin analogs containing α-aminoisobutyric acid with potent anticancer activity. Sudhanand Prasad, Archna Mathur, Neena Gupta, Manu Jaggi, Anu T Singh, Praveen Rajendran, Vinod Sanna, Kakali Dutta and Rama Mukherjee. J Pept Sci. 2007 Jan; 13(1):54-62.
http://www.ncbi.nlm.nih.gov/pubmed/17031871 -
Substance P analogs containing alpha, alpha-dialkylated amino acids with potent anticancer activity. Prasad S, Mathur A, Jaggi M, Singh AT, Mukherjee R. J Pept Sci 2007; 13(8):544-8.
http://www.ncbi.nlm.nih.gov/pubmed/17617800 -
Delivering multiple anticancer peptides as a single prodrug using lysyl-lysine as a facile linker. Prasad S, Mathur A, Jaggi M, Mukherjee R. J Pept Sci 2007; 13(7):458-67.
http://www.ncbi.nlm.nih.gov/pubmed/17559067 -
Concurrent determination of topotecan and model permeability markers (atenolol, antipyrine, propranolol and furosemide) by reversed phase liquid chromatography: Utility in Caco-2 intestinal absorption studies, Bansal T, Singh M, Mishra G, Talegaonkar S, Khar RK, Jaggi M, Mukherjee, R. J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Oct 10, J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Nov 15, Epub 2007 Nov 1; 859(2):261-6.
http://www.ncbi.nlm.nih.gov/pubmed/17936093 -
Bombesin analogs containing alpha-amino-isobutyric acid with potent anticancer activity. Prasad S, Mathur A, Gupta N, Jaggi M, Singh AT, Rajendran P, Sanna VK, Datta K, Mukherjee R. J Pept Sci 2007; 13(1):54-62.
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Anticancer and anti-inflammatory activities of 1,8-naphthyridine-3-carboxamide derivatives. Srivastava SK, Jaggi M, Singh AT, Madaan A, Rani N, Vishnoi M, Agarwal SK, Mukherjee R, Burman AC. Bioorg Med Chem Lett. 2007 Dec 1, Epub 2007 Aug 11; 17(23):6660-4.
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Prasad S, Mathur A, Jaggi M, Singh AT, Mukherjee R. Substance P analogs containing alpha,alpha- dialkylated amino acids with potent anticancer activity. J Pept Sci. 2007 Aug;13(8):544-8. doi: 10.1002/psc.886. PMID: 17617800.
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"Sesquiterepene Lactone Derivatives: Synthesis and their Cytotoxicity". Sanjay K. Srivastava, Manu Jaggi, Anu T. Singh, Aji Abraham, Shiv K. Agarwal, Rama Mukherjee and Anand C. Burman. International conference on Advances in Drug Discovery Research (ISCBC) February 24- 26, 2007 at Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, India 2006 Aug 15;16(16):4195–4199.
https://iscbindia.com/phocadownload/proceedings/Abstract-Book-ISCBC-2007.pdf (Ref. IL-9) -
Octapeptide analogs of somatostatin containing α , α - dialkylated amino acids with potent anticancer activity. Sudhanand Prasad, Archna Mathur, Rajan Sharma, Neena Gupta, Rinku Ahuja, Manu Jaggi, Anu T.Singh and Rama Mukherjee. American Peptide Symposia. Understanding Biology Using Peptides; 2006 1(9): Part 8:639-640.
http://www.springerlink.com/index/h7t15q7717350317.pdf -
Vivekanandan K, Swamy MG, Prasad S, Maikap GC, Mukherjee R, Burman AC. Identification of degradation products from aqueous carboplatin injection samples by electrospray mass spectrometry. Int J Pharm. 2006 Apr 26;313(1-2):214-21. doi: 10.1016/j.ijpharm.2006.02.002. Epub 2006 Mar 10. PMID: 16529885.
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Vivekanandan K, Swamy MG, Prasad S, Mukherjee R, Burman AC. Identification of isocephalomannine in the presence of cephalomannine isomers and alkali metal ion adducts in a paclitaxel active pharmaceutical ingredient using electrospray tandem mass spectrometry. Rapid Commun Mass Spectrom. 2006;20(11):1731-5. doi: 10.1002/rcm.2500. PMID: 16676315.
https://pubmed.ncbi.nlm.nih.gov/16676315/ -
Octapeptide analogs of Somatostatin containing α , α - Dialkylated amino acids with potent anticancer activity. Sudhanand Prasad, Archna Mathur, Rajan sharma, Neena Gupta, Rinku Ahuja, Manu Jaggi, Anu T. Singh & Rama Mukherjee. International Journal of Peptide research & therapeutics 2006 Jun 2006; 12(2):179-185.
www.springerlink.com/index/h7t15q7717350317.pdf -
Synthesis of 13-Amino Costunolide derivatives as Anticancer Agents. Sanjay K. Srivastava, Aji Abraham, Beena Bhat, Manu Jaggi, Anu T. Singh, Vinod K. Sanna, Gurvinder Singh, Shiv K. Agarwal, Rama Mukherjee and Anand C. Burman. Boiorg. Med. Chem Lett. 2006, 16:4195-4199.
http://www.ncbi.nlm.nih.gov/pubmed/16766184 -
Furanoid Sugar Amino Acids in Design of Analogs of VIP Receptor Binding Inhibitor. Sudhanand Prasad, Archna Mathur, Manu Jaggi, Rajan Sharma, Neena Gupta, Rama Mukherjee, Ajit C Kunwar and Tushar K Chakraborty. Understanding Biology Using Peptides, Proceedings of the 19th American Peptide Symposium, 2005; 661-662.
http://www.springerlink.com/index/h16720np55851540.pdf PDF not available -
Porchezhian E, Ansari SH. Hepatoprotective activity of Abutilon indicum on experimental liver damage in rats. Phytomedicine. 2005 Jan;12(1-2):62-4. doi: 10.1016/j.phymed.2003.09.009. PMID: 15693709.
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Vivekanandan K, Swamy MG, Prasad S, Mukherjee R. A simple method of isolation of chloramphenicol in honey and its estimation by liquid chromatography coupled to electrospray ionization tandem mass spectrometry. Rapid Commun Mass Spectrom. 2005;19(21):3025-30. doi: 10.1002/rcm.2169. PMID: 16193535.
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DRF7295: A novel peptide based signal transcluction modulator for the treatment of gastrointestinal carcinomas. Singh, AT, Jaggi, M, Prasad, S, Singh, G, Dutta, K, Rajendran, P, Burman, AC, Mukherjee, R. Clin. Cancer Research 2005; 11:9010S.
http://www.ncbi.nlm.nih.gov/pubmed/18322652 -
Anticancer activity of DRF7295: A peptide combination targeting multiple neuropeptide receptors in gastrointestinal cancers. Jaggi, M, Singh, AT, Prasad, S, Rajendran, P, Dutt, S, Burman, AC, Mukherjee, R. Clin. Cancer Research 2005; 11:9081S-9082S.
http://www.ncbi.nlm.nih.gov/pubmed/18217205 -
A Peptide Combination Targeting Multiple Neuropeptide Receptors for the Treatment of Gastrointestinal carcinomas. Manu Jaggi, Anu T. Singh, Sudhanand Prasad, Praveen R, Sarjana Dutt, Anand C. Burman, Rama Mukherjee. Anticancer Activity of DRF7295: Abstract accepted for the international Conference on Molecular targets and cancer therapeutics AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, Philadelphia, Pennsylvania Nov 14 –18th 2005, Published in Clin. Cancer Res 2005 Dec 15; 11,24 (Suppl) abstract No .B198
http://www.ncbi.nlm.nih.gov/pubmed/18217205 PDF Not available -
A novel peptide based signal transduction modulator for the Treatment of Gastrointestinal carcinomas. Anu T. Singh, Manu Jaggi, Sudhanand Prasad, Gurvinder Singh, Kakali Datta, Praveen Rajendran, Anand C. Burman, Rama Mukherjee. DRF7295: Abstract accepted for Meeting on Molecular targets and cancer therapeutics AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, Philadelphia, Pennsylvania Nov 14 –18th 2005. Published in Clin. Cancer Res. Dec 15, 2005; 11, 24 (Suppl) Abstract No. A186.
https://www.researchgate.net/publication/296315523_DRF7295_A_novel_peptide_based_sign al_transcluction_modulator_for_the_treatment_of_gastrointestinal_carcinomas PDF Not available -
Octapeptide analogs of somatostatin containing α, α- di-alkylated amino acids with potent anticancer activity. Sudhanand Prasad, Archna Mathur, Neena Gupta, Manu Jaggi, Anu T Singh and Rama Mukherjee. Understanding Biology Using Peptides, Proceedings of the 19th American Peptide Symposium, 2005:639-640. International Journal of Peptide Research and
Therapeutics 2006; 12(2):179-185. -
Furanoid sugar amino acids as dipeptide mimics in design of analogs of vasoactive intestinal peptide receptor binding inhibitor. Prasad S, Mathur A, Jaggi M, Sharma R, Gupta N, Reddy VR, Sudhakar G, Kumar SU, Kumar SK, Kunwar AC and Chakraborty TK. J. Peptide Res. 2005; 66:75-84.
http://www.ncbi.nlm.nih.gov/pubmed/16000121 -
Katiyar CK, Arora D, Mehrotra R, Nandi AR, Dutta A, Jain AK. Management of chronic hepatitis B with New Livfit in end stage renal disease. Indian J Physiol Pharmacol. 2005 Jan;49(1):83-8. PMID: 15881863.
https://pubmed.ncbi.nlm.nih.gov/15881863/ PDF Not available -
Synthesis of 3-O-acyl/3-benzylidene/3-hydrazone/3-hydrazine/17-carboxyacryloyl ester derivatives of betulinic acid as anti-angiogenic agents. Mukherjee Rama, Jaggi Manu, Rajendran Praveen, Srivastava Sanjay K, Siddiqui Mohammad JA, Vardhan Anand, Burman Anand C.
Divisions of Experimental Oncology, Dabur Research Foundation, U.P., Ghaziabad, India. Bioorg & Med Chem Lett. 2004; 14(12):3169-3172. Publisher: Elsevier Science B.V., CODEN: BMCLE8 ISSN: 0960-894X. Journal written in English. CAN 141:123780 AN2004:403830 CAPLUS
(Copyright (C) 2005 ACS on SciFinder (R)). doi:10.1016/j.bmcl.2004.04.010
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Mukherjee R, Jaggi M, Siddiqui MJ, Srivastava SK, Rajendran P, Vardhan A, Burman AC. Synthesis and cytotoxic activity of 3-O-acyl/3-hydrazine /2-bromo/20,29-dibromo betulinic acid derivatives. Bioorg Med Chem Lett. 2004 Aug 2;14(15):4087-91. doi: 10.1016/j.bmcl.2004.05.034. PMID: 15225732.
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Mukherjee R, Jaggi M, Rajendran P, Siddiqui MJ, Srivastava SK, Vardhan A, Burman AC. Betulinic acid and its derivatives as anti-angiogenic agents. Bioorg Med Chem Lett. 2004 May 3;14(9):2181-4. doi: 10.1016/j.bmcl.2004.02.044. PMID: 15081004.
Betulinic acid and its derivatives as anti-angiogenic agents - PubMed (nih.gov) -
Khullar P, Khar RK, Agarwal SP. Evaluation of guar gum in the preparation of sustained- release matrix tablets. Drug Dev Ind Pharm. 1998 Nov;24(11):1095-9. doi: 10.3109/03639049809089955. PMID: 9876566.
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Vishwanath R. The psychoneuroimmunological system: a recently evolved networking organ system. Med Hypotheses. 1996 Oct;47(4):265-8. doi: 10.1016/s0306-9877(96)90064-x. PMID: 8910873.
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Alka Madaan, Pratibha Singh, Anshumali Awasthi, Ritu Verma, Anu T. Singh, Manu Jaggi, Shiva Kant Mishra, Sadanand Kulkarni, Hrishikesh Kulkarni Determination of Antioxidant and Hepatoprotective Ability of Flavanoids of Cichorium intybus. Clin Transl Oncol. doi 10.1007/s12094-012-0883-2
https://www.academia.edu/52973457/Determination_of_Antioxidant_and_Hepatoprotective_Ability_of_Flavanoids_ofCichorium_Intybus -
Navika Gupta, Anu. T.Singh. Toxicological evaluation of oleanolic acid (pentacyclic triterpenoid) extracted from lantana camara roots following oral exposure in wistar rats.
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Microorganism Assisted Synthesis of Gold Nanoparticles: A Review Accepted on November 17, 2017 Visit for more related articles at Asian Journal of Biomedical and Pharmaceutical Sciences Nikita Sehgal, Kriti Soni*, Navika Gupta
https://www.alliedacademies.org/articles/microorganism-assisted-synthesis-of-gold-nanoparticles-a-review-10094.html -
A Critical Review: General Toxicity, Its Types, Methodology, and Applications in Industry & Academia. Nikita Sehgal, Kriti Soni*, Navika Gupta and Nidhi Gupta.
https://www.wjpps.com/wjpps_controller/abstract_id/7470 -
Review Article on Dose-Response relationship In Toxicology *Navika Gupta, Anu T. Singh and Manu jaggi
https://www.wjpps.com/wjpps_controller/abstract_id/9963