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EX-Vivo Models

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HAIR GROWTH

  • Hair morphology by SEMDRF/CB/EXV-01

    Hair morphology by SEM in Human hair tresses to study Smoothening/ Conditioning/Strengthening properties.

    • Cell Model

      Human hair tresses

    • End Point

      Improvement of hair surface structure (Restoration slate-like hair scale, Absence of any lifted scales)

    • Reference Drugs

      NA

    • Relevance

      Smoothening/ Conditioning/Strengthening properties
  • Coloration/Discoloration of hairDRF/CB/EXV-02

    Coloration/Discoloration of hair in Human hair tresses to study Hair coloration/photo- discoloration.

    • Cell Model

      Human hair tresses

    • End Point

      Hair color protection

    • Reference Drugs

      NA

    • Relevance

      Hair coloration/photo- discoloration
  • Protection against UVB damage- visual and protein contentDRF/CB/EXV-03

    Protection against UVB damage- visual and protein content in Human hair tresses to study Prevention of Hair photodamage.

    • Cell Model

      Human hair tresses

    • End Point

      Hair surface structure protection

    • Reference Drugs

      NA

    • Relevance

      Prevention of Hair photodamage
  • Hair sensorial assessmentDRF/CB/EXV-04

    Hair sensorial assessment in Human hair tresses to study Smoothening/Conditioning/Strengthening properties.

    • Cell Model

      Human hair tresses

    • End Point

      Smoothness, Wet and dry combability, Bounce, Detangling, Gloss and Shine Hair breakage

    • Reference Drugs

      NA

    • Relevance

      Smoothening/Conditioning/Strengthening properties

CATARACT

  • Ex vivo anticataract activity using mice eye modelDRF/CB/EXV-05

    Ex vivo anticataract activity using mice eye model in C57BL/6 mice eye to study Anti-cataract activity.

    • Cell Model

      C57BL/6 mice eye

    • End Point

      Lens opacity, Antioxidant screening

    • Reference Drugs

      Triphala

    • Relevance

      Anti-cataract activity

PEDICULICIDAL AND OVICIDAL EFFICACY

  • Pediculicidal and Ovicidal efficacy against Head LiceDRF/CB/EXV-06

    Pediculicidal and Ovicidal efficacy against Head Lice to evaluate Anti-pediculicidal activity using Adult & nymph head lice from human volunteer, measuring % Pediculicidal activity (Mortality of adult lice and nymphs).

    • Cell Model

      Adult & nymph head lice from human volunteer

    • End Point

      % Pediculicidal activity (Mortality of adult lice and nymphs); % Ovicidal activity (Hatching rate of nits)

    • Reference Drugs

      1% Perlice/ Mediker

    • Relevance

      Anti-pediculicidal activity

ACARICIDAL ACTIVITY

  • Acaricidal activity efficacy against anti-ticksDRF/CB/EXV-07

    Acaricidal activity efficacy against anti-ticks to evaluate Acaricidal activity using Ticks from dogs, measuring Hot plate observation, % Mortality.

    • Cell Model

      Ticks from dogs

    • End Point

      Hot plate observation, % Mortality

    • Reference Drugs

      Amitraz

    • Relevance

      Acaricidal activity

DERMAL SAFETY

  • Zein test- Skin irritation and corrosivityDRF/CB/EXV-08

    Zein test- Skin irritation and corrosivity to evaluate Skin Irritation potential using Zein protein, measuring Zein number or Post treatment TI dry weight.

    • Cell Model

      Zein protein

    • End Point

      Zein number or Post treatment TI dry weight

    • Reference Drugs

      SDS

    • Relevance

      Skin Irritation potential

TOOTH WHITENING

  • Ex-vivo model to assess tooth whitening efficacy using HA DiscDRF/CB/EXV-09

    Ex-vivo model to assess tooth whitening efficacy using HA Disc to evaluate Color difference using Stained hydroxyapatite (HA) disc, measuring Improvement in whiteness.

    • Cell Model

      Stained hydroxyapatite (HA) disc

    • End Point

      Improvement in whiteness

    • Reference Drugs

      Colgate visible white

    • Relevance

      Color difference

ANTICANCER XENOGRAFT

  • In-ovo anticancer xenograft using CAM modelDRF/CB/EXV-10

    In-ovo anticancer xenograft using CAM model to evaluate Tumor size and weight reduction using Chorioallantoic membrane??of fertilized chicken egg, measuring Tumor size and weight reduction.

    • Cell Model

      Chorioallantoic membrane?of fertilized chicken egg

    • End Point

      Tumor size and weight reduction

    • Reference Drugs

      Docetaxel

    • Relevance

      Tumor size and weight reduction

ONYCHOMYCOSIS ACTIVITY

  • Ex-vivo onychomycosis using human nail modelDRF/CB/EXV-11

    Ex-vivo onychomycosis using human nail model in Human nails samples to study Anti-fungus activity.

    • Cell Model

      Human nails samples

    • End Point

      Measurement of Zone of inhibition

    • Reference Drugs

      Clotrimazole powder

    • Relevance

      Anti-fungus activity

Ex-Vivo

  • Ex-vivo haemolysis assay using bloodPCY/GI-01

    Ex-vivo hemolysis assay using blood measures the percentage of hemolysis to evaluate the cytotoxic effects of various substances on red blood cells under experimental conditions.

    • Cell Model

      Rabit blood

    • End Point

      % Hemolysis

    • Reference Drugs

      10% TritonX-100