Skip to main content

Ophthalmology

Discovery Services

Select Service Type

  • Cytoprotection in retinal cells (ARPE-19) against oxidative stressDRF/CB/AMT-01

    This assay assesses cytoprotection in retinal pigmented epithelial cells (ARPE-19) against oxidative stress by evaluating the restoration of cell viability.

    • Cell Model

      Retinal Pigmented epithelial Cells (ARPE-19)

    • End Point

      Restoration of cell viability

    • Reference Drugs

       L-ascorbic acid, cysteine

    • Relevance

      Occular protection
  • Apoptosis in retinal cells (ARPE-19) against oxidative stressDRF/CB/AMT-01

    This assay evaluates apoptosis in retinal pigmented epithelial cells (ARPE-19) under oxidative stress, assessing the anti-apoptotic potential to mitigate cellular damage.

    • Cell Model

      Retinal Pigmented epithelial Cells (ARPE-19)

    • End Point

      Anti-apoptotic potential against damage

    • Reference Drugs

       L-ascorbic acid, cysteine

    • Relevance

      Occular protection
  • Cytokines release in retinal/corneal cell line (panel available on request)DRF/CB/AMT-01

    This assay measures cytokine release in a retinal/corneal cell line , assessing the percent inhibition of cytokine levels in retinal pigmented epithelial cells (ARPE-19) to evaluate anti-inflammatory effects.

    • Cell Model

      Retinal Pigmented epithelial Cells (ARPE-19)

    • End Point

      Percent inhibition of levels of cytokines

    • Reference Drugs

       Diclofenac/ Dexamethasone

    • Relevance

      Occular Inflammation
  • Biomarker analysis by multiplexingDRF/CB/AMT-01

    This assay analyzes biomarkers through multiplexing in retinal pigmented epithelial cells (ARPE-19), assessing the modulation of key biomarkers involved in cellular processes.

    • Cell Model

      Retinal Pigmented epithelial Cells (ARPE-19)

    • End Point

      Modulation of key biomarkers involved

    • Reference Drugs

      Diclofenac/ Dexamethasone

    • Relevance

      Occular Inflammation
  • Sodium selenite-induced cataract model PCY/OP-01

    Sodium selenite-induced cataract model in rat pups, measuring cataract grade, opacity score, and slit lamp examination.

    • Animal Model

      Rat Pups

    • End Point

      Cataract grade, Opacity score of isolated lens, Slit lamp examination

    • Reference Drugs

      `--
  • Cornea damage model PCY/OP-02

    Cornea damage model in New Zealand rabbits, assessing OCT imaging, slit lamp examination, histology, and intraocular pressure.

    • Animal Model

      New Zealand Rabbit

    • End Point

      OCT imaging, Slit lamp examination, Histology, Intraocular Pressure

    • Reference Drugs

      `--
  • Intraocular Pressure modelPCY/OP-03

    Intraocular pressure model in New Zealand rabbits, measuring OCT imaging, slit lamp examination, and intraocular pressure.

    • Animal Model

      New Zealand Rabbit

    • End Point

      OCT imaging, Slit lamp examination, Histology, Intraocular Pressure

    • Reference Drugs

      `--
  • Diabetes induced cataract and Retinopathy model PCY/OP-04

    Diabetes-induced cataract and retinopathy model in rats, assessing OCT imaging, slit lamp examination, and intraocular pressure.

    • Animal Model

      Wistar/SD Rats

    • End Point

      OCT imaging, Slit lamp examination, Histology, Intraocular Pressure

    • Reference Drugs

      `--
  • BAC- induced Dry eye model PCY/OP-05

    BAC-induced dry eye model in mice, measuring OCT imaging, slit lamp examination, tear volume, and intraocular pressure.

    • Animal Model

      BALB/c Mice

    • End Point

      OCT imaging, Slit lamp examination, Histology, Intraocular Pressure,Tear Volume

    • Reference Drugs

      Restasis